Cerebral palsy (CP), a neurological disorder, has no known cure. The treatments with medicines, surgery and rehabilitation therapies may improve the child’s condition but the satisfactory outcome has not yet been achieved. Human embryonic stem cells (hESCs) therapy has been used for the treatment of neurodegenerative and neurological disorders. Here we report findings of two patients suffering from CP, after undergoing treatment with hESC therapy. The treatment consisted of phases in which 0.25 mL (< 4 million cells) hESCs was administered through intramuscular route once daily and 1 mL of hESCs (< 16 million cells) was administered through intravenous route twice every 7 days. A marked improvement in cognitive and motor functions was seen in the patients after the treatment.